HCID 89580563, compound → 4-(4-cyanophenoxy)benzoic acid

HRID 1501230Notes

Reaction equation

HRID 1501230 reaction equation
[C:1]([C:3]1[CH:22]=[CH:21][C:6]([O:7][C:8]2[CH:20]=[CH:19][C:11]([C:12]([O:14]C(C)(C)C)=[O:13])=[CH:10][CH:9]=2)=[CH:5][CH:4]=1)#[N:2]>ClCCl.FC(F)(F)C(O)=O>[C:1]([C:3]1[CH:22]=[CH:21][C:6]([O:7][C:8]2[CH:20]=[CH:19][C:11]([C:12]([OH:14])=[O:13])=[CH:10][CH:9]=2)=[CH:5][CH:4]=1)#[N:2]

Participants

3

Reactant 1

HCID 89580563HCID 89580563, compound

Product 1

HCID 21798064-(4-cyanophenoxy)benzoic acidYield 70%

Reagents, catalysts & solvents 1

HCID 21863450Trifluoroacetic acid methylene chlorideSolvent

Procedure

The solution of tert-butyl 4-(4-cyanophenoxy)benzoate (80 mg, 0.27 mmol) in dichloromethane: trifluoroacetic acid (4:1, 3 mL) was stirred overnight at room temperature. The solvent was evaporated in vacuo to give 4-(4-cyanophenoxy)benzoic acid (45 mg, 70%). LRMS (M+H+) m/z: calcd 239.06. found 239.

Workup

  1. customThe solvent was evaporated in vacuo

Sources & evidence

ORD record
ord-b779efa73555450e8f2c61880b27a863
Source dataset
uspto-grants-2015_12
Patent number
US09206128B2

Reaction notes

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