Methanol → Methyl 2-(4-bromophenyl)acetate

Participants

Reaction Steps

To a solution of 2-(4-bromophenyl)acetic acid (10 g, 47 mmol) in methanol (100 mL) was dropwise thionyl chloride (0.2 mL) at room temperature. The mixture solution was heated to reflux for 3 hours. Then removed the solvent to dry to gave methyl 2-(4-bromophenyl)acetate as a colorless oil (10 g, 94%). 1H NMR (300 MHz, CDCl3): δ 7.45 (d, J=9 Hz, 2H), 7.15 (d, J=9 Hz, 2H), 3.70 (s, 3H), 3.58 (s, 2H).

Provenance & Evidence