Hydrochloric Acid → HCID 89581499, compound

Participants

Reaction Steps

A suspension solution of methyl 4-(1-phenoxypropan-2-yl)benzoate (0.1 g, 0.4 mmol) and lithium hydroxide (48 mg, 2 mmol) in tetrahydrofuran (20 mL) and water (10 mL) was stirred at room temperature for 2 hours. The mixture solution was diluting with ethyl acetate (50 mL), and acidified with hydrochloric acid to PH<4. The organic layer was separated, dried over sodium sulfate, and concentrated to dry. The residue 4-(1-phenoxypropan-2-yl)benzoic acid (60 mg, 65%) was used directly for the next step without purification.

Provenance & Evidence