1,2-Dichloroethane → HCID 89582846, compound

Participants

Reaction Steps

In a pyrex vial 3-(aminomethyl)-4-methyl-6,7-dihydro-1H-cyclopenta[b]pyridin-2(5H)-one (35 mg, 0.21 mmol), 4-phenoxybenzoic acid (50 mg, 0.23 mmol), HOBT (36 mg, 0.23 mmol) and DMF (1.5 mL) were cooled to 0° C. EDC (45 mg, 0.23 mmol) was then added in one portion and the cold bath was removed. The reaction was mixed at ambient temperature overnight then diluted with MeOH (2 mL) and water (1 mL), filtered through a PTFE screen and purified by reverse-phase HPLC 10-95% gradient of MeCN in water (0.1% TFA). The product fractions were lyophilized to produce N-((2-oxo-2,5,6,7-tetrahydro-1H-cyclopenta[b]pyridin-3-yl)methyl)-4-phenoxybenzamide as a white solid (43 mg, 56%). 1H NMR (400 MHz, DMSO-d6) δ 8.70 (t, J=5.71 Hz, 1H), 7.87-7.96 (m, 2H), 7.38-7.47 (m, 2H), 7.15-7.23 (m, 2H), 7.05-7.11 (m, 2H), 6.99-7.05 (m, 2H), 4.19 (d, J=5.61 Hz, 2H), 2.69 (t, J=7.48 Hz, 2H), 2.58 (t, J=7.17 Hz, 2H), 1.98 (quin, J=7.43 Hz, 1H). LRMS (M+H+) m/z: calcd 361.15. found 361.2.

Provenance & Evidence