HuagongsheHuagongshe Chemistry Print Report · For research reference only
Menthol → Methyl 2-(4-bromophenyl)acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Menthol | HCID 1254 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | Benzeneacetic acid, 4-bromo- | HCID 74654 | — |
| Product | Methyl 2-(4-bromophenyl)acetate | HCID 316783 | 99.8% |
Reaction Steps
To a solution of 2-(4-bromophenyl)acetic acid (10 g, 46.7 mmol) in menthol was added thionyl chloride (8.34 g, 70.07 mmol) dropwise. The mixture was then stirred at room temperature for 18 hours. The reaction mixture was concentrated, and obtained methyl 2-(4-bromophenyl)acetate (10.5 g, 99.8%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09206128B2 |
| Source dataset | uspto-grants-2015_12 |
| ORD ID | ord-288fa4685a594942b3a075c8373571ef |
| Source note | uspto-grants-2015_12 |