Ammonia methanol → HCID 178428521, compound

Participants

Reaction Conditions

Reaction Steps

To a pressure vessel were added 4-chloro-2-hydroxy-6-methylnicotinonitrile (600 mg, 3.6 mmol), ammonia methanol solution (7 mol/L, 15 mL) and magnetic stirrer. The pressure vessel was sealed, and stirred at 100° C. for 16 hours. After being cooled to room temperature, the solvent and excess ammonia were removed by rotary evaporation. The residue was purified by silica gel column chromatography with dichloromethane/methanol=10:1 to afford 4-amino-2-hydroxy-6-methylnicotinonitrile (350 mg, 66% yield) as a brown solid.

Provenance & Evidence