Methylamine tetrahydrofuran → HCID 178482200, compound

Participants

Reaction Conditions

Reaction Steps

To a pressure vessel were added 4-chloro-2-hydroxy-6-methylnicotinonitrile (337 mg, 2.0 mmol), methylamine tetrahydrofuran solution (2 mol/L, 15 mL), and magnetic stirrer. The pressure vessel was sealed, and it was stirred at 90° C. for 2 hours. After being cooled to room temperature, the vessel was opened, and the reaction solution was transferred to an eggplant-shaped bottle. The solvent and excess methylamine were removed by rotary evaporation. The residue was purified by silica gel column chromatography with dichloromethane/methanol=10:1 to afford 2-hydroxy-6-methyl-4-(methylamino)nicotinonitrile (200 mg, 61% yield) as a brown solid. 1H NMR (300 MHz, methanol-d4): δ 5.89 (s, 1H), 3.56 (d, J=10.8 Hz, 3H), 2.94 (s, 1H), 2.55 (s, 1H), 2.24 (s, 1H).

Provenance & Evidence