Triethylamine → N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3,5-dimethyl-2-oxo-1-(1-phenylethyl)-1,2-dihydropyridine-4-carboxamide

Participants

Reaction Steps

To a solution of 3,5-dimethyl-2-oxo-1-(1-phenylethyl)-1,2-dihydropyridine-4-carboxylic acid (0.07 g, 0.26 mmol) in dichloromethane (10 mL) was added EDCI (0.06 g, 0.39 mmol), HOBt (0.05 g, 0.38 mmol) and triethylamine (0.078 g, 0.77 mmol). After stirred for 30 min, 3-(aminomethyl)-4,6-dimethyl pyridin-2(1H)-one (0.058 g, 0.39 mmol) was added and the reaction mixture was stirred at room temperature for 3 hours. The solution was concentrated under vacuum. The residue was diluted with water (20 mL) and extracted with ethyl acetate (20 mL). The extractions were combined, washed with H2O, dried over Na2SO4, and concentrated under vacuum. The residue was purified by prep. HPLC (Condition: Column: YMC C18 150*30 mm*5 um; Mobile phase A: water with 0.05% ammonia solution Mobile phase B: MeCN; column temperature: 30° C.; Gradient: A/B, 35-65%) to give N-((4,6-dimethyl-2-oxo-1,2-dihydropyridin-3-yl)methyl)-3,5-dimethyl-2-oxo-1-(1-phenylethyl)-1,2-dihydropyridine-4-carboxamide as yellow solid. (7.5 mg, yield 7.1%)

Provenance & Evidence