Hydrochloric Acid → HCID 178507127, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of tert-butyl (1-{4-[3-phenyl-6-methoxyimidazo[1,2-b]pyridazin-2-yl]phenyl}cyclobutyl)carbamate that was prepared in a manner analgous to that described for Intermediate Example Int-5 (0.25 g, 0.53 mmol) in N-methylpyrrolidone (5 mL) was warmed to 100° C., then sodium sulfide (0.21 g, 2.66 mmol, 5.0 equiv) was added and the mixture was heated to 160° C. for 10 minutes. The resulting mixture was added to ice water (15 mL). The aqueous mixture was made acidic with an aqueous 2 N HCl solution, then was buffered with a saturated aqueous sodium bicarbonate solution. The resulting precipitate was removed by filtration, washed with water, and dried at 50° C. under vacuum to give 2-[4-(1-Aminocyclobutyl)phenyl]-3-phenylimidazo[1,2-b]pyridazin-6-ol (0.10 g, 53%):

Provenance & Evidence