Dimethylformamide → 4-(4-bromo-1H-pyrazol-1-yl)-1H-pyrrolo[2,3-b]pyridine

Participants

Role	Name	HCID	Charge
Reactant	Dimethylformamide	HCID 6228	—
Reactant	4-Bromopyrazole	HCID 16375	—
Reactant	4-Bromo-1H-pyrrolo[2,3-b]pyridine	HCID 22273643	—
Solvent	Ethyl Acetate	HCID 8857	—
Product	4-(4-bromo-1H-pyrazol-1-yl)-1H-pyrrolo[2,3-b]pyridine	HCID 57477672	—

Reaction Conditions

Temperature	150 °C

Reaction Steps

A mixture of 4-bromo-1H-pyrrolo[2,3-b]pyridine (1.10 g, 0.00558 mol) and 4-bromo-1H-pyrazole (1.2 g, 0.0084 mol) was heated neat to 150° C. for 2 h. DMF was added to dissolve the crude residue. This residue was taken up in EtOAc and washed with 1N NaOH. The organic layer was washed with brine, dried over MgSO4, filtered and concentrated to give a crude 4-(4-bromo-1H-pyrazol-1-yl)-1H-pyrrolo[2,3-b]pyridine residue, LC/MS (M+H)+: 263, 265.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US09206187B2
Source dataset	uspto-grants-2015_12
ORD ID	ord-b11a5a3726524609aa3a256761b09feb
Source note	uspto-grants-2015_12