p-Toluenesulfonic acid monohydrate → HCID 86709437, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of (S)-4-methyl-5-(oxiran-2-yl)isobenzofuran-1(3H)-one (2.00 g, 10.5 mmol) in MeOH (20 mL) was added p-toluenesulfonic acid monohydrate (0.100 g, 0.526 mmol). After heating at 80° C. for 48 h, the reaction mixture was cooled to RT and then concentrated. The crude product was purified by column chromatography eluting with 0-45% EtOAc/Hexane. LC-MS (IE, m/z): 223.2 (M+1)+.

Provenance & Evidence