Ethyl Acetate → HCID 66646404, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 5-bromo-4-(2-hydroxyethyl)-2-benzofuran-1(3H)-one (0.460 g, 1.78 mmol), tributyl(vinyl)tin (0.676 g, 2.13 mmol), LiCl (0.224 g, 5.33 mmol) and Pd (PPh3)4 (0.10 g, 0.087 mmol) in toluene (50 mL) was heated at 100-110° C. under N2 overnight after which TLC indicated that the reaction had gone to completion. Next, EtOAc (100 mL) was poured into the solution and it was washed with brine, then water, then dried over Na2SO4, filtered and concentrated to dryness. The residue was then absorbed onto silica gel and separated over silica column to give the title compound.

Provenance & Evidence