反应详情

温度

110 °C

Tert-butyl 4-formyl-4-propylpiperidinecarboxylate (30 g) was dissolved in a saturated solution of ammonia in methanol, and 15 g of Raney Ni was added. The reaction mixture was heated to 110° C. at 80 atmospheres pressure in a 2 L high-pressure autoclave. The mixture was filtered to remove the catalyst and the filtrate was concentrated to give residue which was purified by column chromatography to afford tert-butyl 3,8-diazaspiro[5,5]undecane-3-carboxylate.

1. additionwas added
2. filtrationThe mixture was filtered
3. customto remove the catalyst
4. concentrationthe filtrate was concentrated
5. customto give residue which
6. customwas purified by column chromatography