HCID 66643955, compound → HCID 66643986, compound

HRID 1501823Notes

Reaction equation

HRID 1501823 reaction equation
[Br:1][C:2]1[CH:11]=[CH:10][C:5]2[C:6](=[O:9])[O:7][CH2:8][C:4]=2[C:3]=1[CH:12]=[CH2:13]>CO>[Br:1][C:2]1[CH:11]=[CH:10][C:5]2[C:6](=[O:9])[O:7][CH2:8][C:4]=2[C:3]=1[CH2:12][CH3:13]

Participants

3

Reactant 1

HCID 66643955HCID 66643955, compound

Product 1

HCID 66643986HCID 66643986, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of 5-bromo-4-vinyl-2-benzofuran-1(3H)-one (2.0 g, 8.37 mmol) and PdC (400 mg) in 50 mL of MeOH was stirred at rt. under H2 (1 atm) overnight, and then filtered. The filtrate was concentrated. The resulting oil was purified by column chromatography to give 5-bromo-4-ethyl-2-benzofuran-1(3H)-one.

Workup

  1. filtrationunder H2 (1 atm) overnight, and then filtered
  2. concentrationThe filtrate was concentrated
  3. customThe resulting oil was purified by column chromatography

Sources & evidence

ORD record
ord-d5a689736a0543a2b98b1259b360681f
Source dataset
uspto-grants-2015_12
Patent number
US09206198B2

Reaction notes

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