Ethyl 1-benzyl-4-(cyanomethyl)-3-oxopiperidine-4-carboxylate → Ethyl 4-(2-aminoethyl)-1-benzyl-3-hydroxypiperidine-4-carboxylate

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Reaction Steps

Into a 10000-mL 4-necked round-bottom flask was placed a solution of ethyl 1-benzyl-4-(cyanomethyl)-3-oxopiperidine-4-carboxylate (180 g, 599.30 mmol) in acetic acid/methanol (1:1, 5.4 L) and platinum oxide (27 g, 118.90 mmol). The flask was then flushed and charged with hydrogen and stirred overnight at room temperature. After filtration under nitrogen through CELITE®, the filtrate was concentrated under vacuum to give the title compound.

Provenance & Evidence