Sodium Hypochlorite → HCID 20825144, compound

HRID 1501919Notes

Reaction equation

[C:1]([O:4][C@@H:5]1[CH2:29][CH2:28][C@@:27]2([CH3:30])[CH:7]([CH2:8][C@@H:9]([O:33][C:34](=[O:36])[CH3:35])[C@@H:10]3[C@@H:26]2[CH2:25][C@H:24]([OH:31])[C@@:23]2([CH3:32])[C@H:11]3[CH2:12][CH2:13][C@@H:14]2[C@H:15]([CH3:22])[CH2:16][CH2:17][C:18]([O:20][CH3:21])=[O:19])[CH2:6]1)(=[O:3])[CH3:2].Cl[O-].[Na+]>>[C:1]([O:4][C@@H:5]1[CH2:29][CH2:28][C@@:27]2([CH3:30])[CH:7]([CH2:8][C@@H:9]([O:33][C:34](=[O:36])[CH3:35])[C@@H:10]3[C@@H:26]2[CH2:25][C:24](=[O:31])[C@@:23]2([CH3:32])[C@H:11]3[CH2:12][CH2:13][C@@H:14]2[C@H:15]([CH3:22])[CH2:16][CH2:17][C:18]([O:20][CH3:21])=[O:19])[CH2:6]1)(=[O:3])[CH3:2]

Participants

Reactant 2

HCID 23665760Sodium Hypochlorite

HCID 90030864HCID 90030864, compound

Product 1

HCID 20825144HCID 20825144, compound

Procedure

wherein the oxidation reaction of the methyl 3α,7α-diacetoxy-12α-hydroxycholanate intermediate on the hydroxyl group in position 12, takes place by means of the sodium hypochlorite, to give the methyl 3α,7α-diacetoxy-12-ketocholanate intermediate.

Sources & evidence

ORD record: ord-f823621cc42f46e6b0d709e7bda864d7
Source dataset: uspto-grants-2015_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09206220B2

Reaction notes

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