反应详情

温度

150 °C

4-Methyl-5-oxiran-2-yl-2-benzofuran-1(3H)-one (3.00 g, 15.8 mmol) and (S)-4-N—BOC-2-hydroxymethylpiperazine (5.12 g. 23.7 mmol) were suspended in ethanol (10 mL) in a 20 mL microwave tube. The reaction mixture was degassed and heated in a microwave apparatus for 30 min at 150° C. The reaction mixture was evaporated to dryness, then chromatographed through a 330 g Redi-sep column and eluted with a solvent system of 1:1 EtOAc/hexane to 100% EtOAc to yield the title compound. LC-MS: M+1=407.

1. customThe reaction mixture was degassed
2. customThe reaction mixture was evaporated to dryness
3. customchromatographed through a 330 g Redi-sep column
4. washeluted with a solvent system of 1:1 EtOAc/hexane to 100% EtOAc