Potassium vinyltrifluoroborate → HCID 66643894, compound

Participants

Reaction Conditions

Reaction Steps

4,5-Dibromo-2-benzofuran-1(3H)-one (3.00 g, 10.3 mmol), Potassium vinyltrifluoroborate (12.7 g, 20.6 mmol) and Pd(dppf)Cl2 (839 mg, 1.03 mmol) in TEA (2.7 mL) and EtOH (15 mL) were added to a flask containing a stir bar. The flask was then heated at 60° C. for 2 h. TLC showed clean and complete reaction. The organic residue was dissolved in EtOAc (500 mL) and the solution was washed with brine, dried over sodium sulfate, filtered and concentrated. The resulting organic residue was subjected to purification over silica gel to give 4-bromo-5-ethenyl-2-benzofuran-1(3H)-one.

Provenance & Evidence