関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | tert-butyl (3S)-3-(hydroxymethyl)piperazine-1-carboxylate | HCID 24820294 | — |
| 反応物 | (3R)-3-methyl-6-(2-methyloxiran-2-yl)-3,4-dihydro-1H-isochromen-1-one | HCID 117690299 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | HCID 131734287 | HCID 131734287 | — |
反応手順
A solution of (3R)-3-methyl-6-(2-methyloxiran-2-yl)-3,4-dihydro-1H-isochromen-1-one (598 mg, 2.74 mmol) and tert-butyl (3S)-3-(hydroxymethyl)piperazine-1-carboxylate (770 mg, 3.56 mmol dissolved in EtOH (15 mL) was heated in a sealed tube to 110° C. for 14 hours. The reaction was cooled and concentrated to give crude product which was purified via MPLC (30-80% EtOAc/Hexane) to give the title compound as a mixture of diastereomers: LC-MS: (M+1)+435;
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US09206199B2 |
|---|
| 出典データセット | uspto-grants-2015_12 |
|---|
| ORD ID | ord-515d4e0ba99d435095938238999373d5 |
|---|
| 出典メモ | uspto-grants-2015_12 |
|---|
