HuagongsheHuagongshe Chemistry Print Report · For research reference only
N,O-Dimethylhydroxylamine → 3-Bromo-4-fluoro-N-methoxy-N-methylbenzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N,O-Dimethylhydroxylamine | HCID 14232 | — |
| Reactant | 1,1'-Carbonyldiimidazole | HCID 68263 | — |
| Reactant | 3-Bromo-4-fluorobenzoic acid | HCID 70509 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 3-Bromo-4-fluoro-N-methoxy-N-methylbenzamide | HCID 53417458 | — |
Reaction Steps
A solution of 3-bromo-4-fluorobenzoic acid (100 g, 0.456 mol) and CDI (77.2 g, 0.547 mol) in 1 L of dry DCM was stirred at r.t. for 30 min and then O,N-dimethyl-hydroxylamine (53.4 g, 0.547 mol) was added. The resulted mixture was stirred overnight. The solvents were removed under vacuum and the residue was purified via column chromatograph to afford the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09206199B2 |
| Source dataset | uspto-grants-2015_12 |
| ORD ID | ord-d1a401f9ffa641a79284d1081b5659d8 |
| Source note | uspto-grants-2015_12 |