反应详情

温度

150 °C

6-Fluoro-2-methyl-3-(oxiran-2-yl)benzonitrile (12.0 g, 67.7 mmol) and (S)-4-N—BOC-2-hydroxymethylpiperazine (22.0 g. 102 mmol) were suspended in ethanol (100 mL) then heated in a microwave apparatus for 30 minutes at 150° C. The reaction mixture was cooled and evaporated dryness. The residue was purified by MPLC chromatography through a 330 g Redi-sep column eluting with 5% MeOH/95% EtOAc solvent system to yield the title compound. LC-MS: M+1=394.

1. temperatureThe reaction mixture was cooled
2. customevaporated dryness
3. customThe residue was purified by MPLC chromatography through a 330 g Redi-sep column
4. washeluting with 5% MeOH/95% EtOAc solvent system