反应详情

温度

150 °C

6-Fluoro-2-methyl-3-(2-oxiranyl)benzonitrile (prepared as described above, 4.80 g, 27.1 mmol) and (R)-4-N—BOC-2-hydroxymethyl-piperazine (8.79 g. 40.6 mmol) were suspended in EtOH (30 mL) and heated in a microwave apparatus at 150° C. for 1 h. The reaction mixture was cooled and evaporated to dryness. The residue was purified by chromatography through a 330 g ISCO Redi-sep column eluting with ethyl acetate to 5% MeOH/ethyl acetate to yield the title compound. LC-MS: M+1=394;

1. temperatureThe reaction mixture was cooled
2. customevaporated to dryness
3. customThe residue was purified by chromatography through a 330 g ISCO Redi-sep column
4. washeluting with ethyl acetate to 5% MeOH/ethyl acetate