Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 1502002생성일: 2026년 10월 25일
tert-butyl (3S)-3-(hydroxymethyl)piperazine-1-carboxylate → (3S)-tert-butyl 4-(2-(3-cyano-4-fluoro-2-methylphenyl)-2-hydroxyethyl)-3-(hydroxymethyl)piperazine-1-carboxylate
https://huagongshe.com/reaction/1502002
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | tert-butyl (3S)-3-(hydroxymethyl)piperazine-1-carboxylate | HCID 24820294 | — |
| 반응물 | 6-Fluoro-2-methyl-3-(oxiran-2-yl)benzonitrile | HCID 86647307 | — |
| 용매 | Ethanol | HCID 702 | — |
| 생성물 | (3S)-tert-butyl 4-(2-(3-cyano-4-fluoro-2-methylphenyl)-2-hydroxyethyl)-3-(hydroxymethyl)piperazine-1-carboxylate | HCID 71272768 | — |
반응 단계
A mixture of 6-fluoro-2-methyl-3-(oxiran-2-yl)benzonitrile (785 mg, 4.43 mmol) and (S)-tert-butyl 3-(hydroxymethyl)piperazine-1-carboxylate (1340 mg, 6.2 mmol) in ethanol (10 mL) was heated in microwave at 150° C. for 3 h. The volatile was evaporated and the residue was purified on Biotage using 40-100% ethyl acetate/hexane to give the title compound: LC/MS: (M+1)+: 394.19.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US09206199B2 |
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| 출처 데이터셋 | uspto-grants-2015_12 |
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| ORD ID | ord-2f311955a74b4d2398d0f33b26a934d0 |
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| 출처 메모 | uspto-grants-2015_12 |
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