Water → HCID 131734291, compound

Participants

Reaction Steps

(3S,9aS)-tert-butyl 3-(3-cyano-4-fluoro-2-methylphenyl)hexahydropyrazino[2,1-c][1,4]thiazine-8(1H)-carboxylate (20 mg, 0.051 mmol) was dissolved in acetonitrile (0.5 mL) and water (0.2 ml) and cooled to 0° C. OXONE (86.1 mg, 0.140 mmol) was added. The ice bath was removed and the reaction mixture was stirred at room temperature overnight. LC-MS showed the completion of the reaction. The reaction mixture was diluted with dichloromethane and water. The organic layer was separated and the aqueous layer was extracted with DCM again. The organic layers were combined and washed with brine, dried (Na2SO4) and concentrated: LC-MS: M+1=440, M+41=481.

Provenance & Evidence