HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyanuric chloride → 3-Bromo-6-fluoro-2-methoxybenzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyanuric chloride | HCID 7954 | — |
| Reactant | 3-Bromo-6-fluoro-2-methoxybenzamide | HCID 71270695 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 3-Bromo-6-fluoro-2-methoxybenzonitrile | HCID 71270710 | — |
Reaction Steps
A solution of 3-bromo-6-fluoro-2-methoxybenzamide (14 g, 61 mmol) in 100 mL of DMF was added 2,4,6-trichloro-[1,3,5]triazine (12.3 g, 67.0 mmol) portionwise at 0° C. and stirred for 2 hours before poured to ice/water. The white solid was collected by filtration and was washed with water, dissolved in DCM, dried over anhydrous Na2SO4 and concentrated to afford 3-bromo-6-fluoro-2-methoxybenzonitrile.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09206199B2 |
| Source dataset | uspto-grants-2015_12 |
| ORD ID | ord-1964671127f54b3493649948dbb6ee70 |
| Source note | uspto-grants-2015_12 |