tert-butyl (3S)-3-(hydroxymethyl)piperazine-1-carboxylate → HCID 86727077, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 3-methyl-4-(oxiran-2-yl)thiophene-2-carbonitrile (1.3 g, 7.9 mmol) and tert-butyl (3S)-3-(hydroxymethyl)piperazine-1-carboxylate (2.0 g, 9.5 mmol) in 5 mL of EtOH was heated in a microwave apparatus at 140° C. for 90 minutes and then cooled down. The reaction mixture was concentrated, and the residue was purified by column chromatography (DCM: MeOH=10:1) to afford the title compound.

Provenance & Evidence