HuagongsheHuagongshe Chemistry Print Report · For research reference only
5-Bromo-4-methylpyridine-3-carbonitrile → 5-Ethenyl-4-methylpyridine-3-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 5-Bromo-4-methylpyridine-3-carbonitrile | HCID 7060681 | — |
| Reactant | Potassium vinyltrifluoroborate | HCID 23679353 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 5-Ethenyl-4-methylpyridine-3-carbonitrile | HCID 13943917 | — |
Reaction Steps
A mixture of 5-bromo-4-methylpyridine-3-carbonitrile (4.40 g, 22.3 mmol), potassium vinyltrifluoroborate (3.70 g, 27.9 mmol) and Pd (dppf)2Cl2 (0.4 g) in 30 mL of EtOH and 30 mL of TEA was refluxed under Ar for 4 hours. Concentrated, the residue was purified by column chromatography (petrol ether: EtOAc=50:1) to afford 5-ethenyl-4-methylpyridine-3-carbonitrile.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09206199B2 |
| Source dataset | uspto-grants-2015_12 |
| ORD ID | ord-7445b1458bd54f859535ba0994ba61c8 |
| Source note | uspto-grants-2015_12 |