HuagongsheHuagongshe Chemistry Print Report · For research reference only
(S)-4-methyl-5-(oxiran-2-yl)isobenzofuran-1(3H)-one → (S)-tert-butyl 3-(acetylthiomethyl)-4-((S)-2-hydroxy-2-(4-methyl-1-oxo-1,3-dihydroisobenzofuran-5-yl)ethyl)piperazine-1-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | (S)-4-methyl-5-(oxiran-2-yl)isobenzofuran-1(3H)-one | HCID 59568665 | — |
| Reactant | (S)-tert-butyl 3-(acetylthiomethyl)-4-((R)-2-hydroxy-2-(4-methyl-1-oxo-1,3-dihydroisobenzofuran-5-yl)ethyl)piperazine-1-carboxylate | HCID 86727079 | — |
| Product | (S)-tert-butyl 3-(acetylthiomethyl)-4-((S)-2-hydroxy-2-(4-methyl-1-oxo-1,3-dihydroisobenzofuran-5-yl)ethyl)piperazine-1-carboxylate | HCID 117690268 | — |
Reaction Steps
Synthesis is analogous to that for (S)-tert-butyl 3-(acetylthiomethyl)-4-((R)-2-hydroxy-2-(4-methyl-1-oxo-1,3-dihydroisobenzofuran-5-yl)ethyl)piperazine-1-carboxylate starting from 4-methyl-5-[(2S)-oxiran-2-yl]-2-benzofuran-1(3H)-one: LC/MS: [(M+1)]+=465.3;
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09206199B2 |
| Source dataset | uspto-grants-2015_12 |
| ORD ID | ord-2411ced2f76a49a190048c21896a122d |
| Source note | uspto-grants-2015_12 |