反应详情

A Pyrex vessel was charged with magnetic stirring bar, (2.0 g, 11.42 mmol) of 2-methoxy-4-(oxiran-2-yl)benzonitrile, (3.70 g, 17.12 mmol) of tert-butyl (3R)-3-(hydroxymethyl)piperazine-1-carboxylate, and 6 mL of EtOH. Then it was introduced in the microwave reactor and irradiated at 150° C. for 3 h. The mixture was cooled to room temperature and the solvent was evaporated and the resulting residue was purified by column chromatography (silica gel, 1-20% dichloromethane/MeOH) which afforded the product as a mixture of two diastereomers (1:1) LC/MS: (IE, m/z) [(M+1)-t-Bu]+=336.41

1. additionA Pyrex vessel was charged with magnetic stirring bar
2. additionThen it was introduced in the microwave reactor
3. customirradiated at 150° C. for 3 h
4. customthe solvent was evaporated
5. customthe resulting residue was purified by column chromatography (silica gel, 1-20% dichloromethane/MeOH) which
6. customafforded the product
7. additionas a mixture of two diastereomers (1:1) LC/MS