反应详情

A Pyrex vessel was charged with magnetic stirring bar, (0.350 g, 2.00 mmol) of 2-methoxy-4-(oxiran-2-yl)benzonitrile, (0.457 g, 2.20 mmol) of tert-butyl (3S)-3-(hydroxymethyl)piperazine-1-carboxylate, and 6 mL of EtOH. Then it was introduced in the microwave reactor and irradiated at 150° C. for 3 h. Then the mixture was cooled to RT and the solvent was evaporated and the resulting residue was purified by column chromatography (silica gel, 1-20% dichloromethane/MeOH) which afforded the title compound as a mixture of two diastereomers (1:1). LC/MS: (IE, m/z) [(M+1)-t-Bu]+=336.1.

1. additionA Pyrex vessel was charged with magnetic stirring bar
2. additionThen it was introduced in the microwave reactor
3. customirradiated at 150° C. for 3 h
4. customthe solvent was evaporated
5. customthe resulting residue was purified by column chromatography (silica gel, 1-20% dichloromethane/MeOH) which