HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Bromo-2,6-difluorobenzonitrile → 2,6-Difluoro-4-vinylbenzonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Bromo-2,6-difluorobenzonitrile | HCID 2756916 | — |
| Reactant | 4-Ethenyl-3-methyl-2-(methyloxy)benzonitrile | HCID 66647291 | — |
| Catalyst | Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+) | HCID 178418228 | — |
| Product | 2,6-Difluoro-4-vinylbenzonitrile | HCID 89619006 | — |
Reaction Steps
2,6-Difluoro-4-vinylbenzonitrile was prepared from 4-bromo-2,6-difluorobenzonitrile using potassium vinyl trifluoroborate and PdCl2(dppf)2 in an analagous fashion as described for 4-ethenyl-3-methyl-2-(methyloxy)benzonitrile above.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09206199B2 |
| Source dataset | uspto-grants-2015_12 |
| ORD ID | ord-fd99baf18d624cd682a48cb97c3d95ee |
| Source note | uspto-grants-2015_12 |