tert-butyl (3S)-3-(hydroxymethyl)piperazine-1-carboxylate → HCID 117690307, compound

Participants

Reaction Steps

2-(2-Methyl-3-nitrophenyl)oxirane (1.47 g, 8.20 mmol) was dissolved in EtOH (10 mL) then added (S)-4N—BOC-2-hydroxymethyl-piperazine (3.19 g, 14.77 mmol) and microwaved at 140° C. for 1 hr. Solvent was evaporated and the residue was purified by chromatography through a 120 g ISCO Redi-Sep column eluting with 0-20% ethyl acetate:hexane to yield the title compound: LC-MS (IE, m/z): 396 [M+1];

Provenance & Evidence