Cyanomethylenetributylphosphorane → HCID 117690357, compound

Participants

Reaction Conditions

Reaction Steps

(3S)-tert-Butyl 4-(2-hydroxy-2-(2-methyl-3-nitrophenyl)ethyl)-3-(hydroxymethyl)piperazine-1-carboxylate (2.15 g, 5.44 mmol) was dissolved in benzene (30 mL) then added cyanomethylenetribuylphosphorane (2.362 g, 9.79 mmol). The mixture was degassed then heated to 100° C. overnight. After cooling, the benzene was evaporated off and the residue was purified by chromatography through a 330 g ISCO Redi-sep column eluting with 5-10% acetone: methylene chloride to yield the title compound: LC-MS (IE, m/z): 378 [M+1]+

Provenance & Evidence