2,3-Dichloro-5-nitropyridine → 2-(3-chloro-5-(1H-tetrazol-1-yl)pyridin-2-yl)acetic acid

HRID 1502111Notes

Reaction equation

HRID 1502111 reaction equation
N1(C2N=CC(CC(O)=O)=CC=2)C=NN=N1.[N:16]1([C:21]2[CH:22]=[CH:23][C:24]([CH2:27][C:28]([OH:30])=[O:29])=[N:25][CH:26]=2)[CH:20]=[N:19][N:18]=[N:17]1.[Cl:31]C1C(Cl)=CC([N+]([O-])=O)=CN=1>>[Cl:31][C:23]1[C:24]([CH2:27][C:28]([OH:30])=[O:29])=[N:25][CH:26]=[C:21]([N:16]2[CH:20]=[N:19][N:18]=[N:17]2)[CH:22]=1

Participants

4

Reactant 3

HCID 27631062,3-Dichloro-5-nitropyridineHCID 66524945[6-(1H-Tetrazol-1-yl)pyridine-3-yl]acetic acidHCID 675176762-(5-(1H-tetrazol-1-yl)pyridin-2-yl)acetic acid

Product 1

HCID 896193822-(3-chloro-5-(1H-tetrazol-1-yl)pyridin-2-yl)acetic acid

Procedure

The title compound was prepared in an analagous fashion to that described for the syntheses of [6-(1H-tetrazol-1-yl)pyridin-3-yl]acetic acid (Steps B-F) and [5-(1H-tetrazol-1-yl)pyridin-2-yl]acetic acid (Steps A-E) starting from 2,3-dichloro-5-nitropyridine. LC/MS: [(M+1-28)]+=212.5.

Sources & evidence

ORD record
ord-b96779bd271d400f88ce4a2c9e8c3b14
Source dataset
uspto-grants-2015_12
Patent number
US09206199B2

Reaction notes

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