HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 2-(5-nitropyrazin-2-yl)acetate → 2-Pyrazineacetic acid, 5-(hydroxyamino)-, ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 2-(5-nitropyrazin-2-yl)acetate | HCID 77230650 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 2-Pyrazineacetic acid, 5-(hydroxyamino)-, ethyl ester | HCID 136278279 | — |
Reaction Steps
A mixture of ethyl (5-nitropyrazine-2-yl)acetate (6.7 g, 31.7 mmol) and Pd/C (1 g, 10%) in 300 mL of EtOAc was stirred at room temperature under hydrogen balloon for 6 hours before filtration. The filtrate was concentrated to afford ethyl[5-(hydroxyamino)pyrazin-2-yl]acetate (incomplete reduction).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09206199B2 |
| Source dataset | uspto-grants-2015_12 |
| ORD ID | ord-2c705a6d842543e2bc5fee15ebdbe5bd |
| Source note | uspto-grants-2015_12 |