HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Pyrazineacetic acid, 5-(hydroxyamino)-, ethyl ester → Ethyl 2-(5-aminopyrazin-2-YL)acetate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Pyrazineacetic acid, 5-(hydroxyamino)-, ethyl ester | HCID 136278279 | — |
| Catalyst | Palladium hydroxide | HCID 9942167 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Ethyl 2-(5-aminopyrazin-2-YL)acetate | HCID 72212710 | — |
Reaction Steps
A mixture of ethyl[5-(hydroxyamino)pyrazin-2-yl]acetate (2.8 g, 14.2 mmol) and Pd(OH)2 (3 g, 10%) in 150 mL of methanol was stirred at room temperature under 50 psi of H2 for 2 hours before filtration. The filtrate was concentrated to afford ethyl (5-aminopyrazin-2-yl)acetate.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09206199B2 |
| Source dataset | uspto-grants-2015_12 |
| ORD ID | ord-81853719f13b4581a7f9fd0862447aca |
| Source note | uspto-grants-2015_12 |