Hydrochloric Acid → 2-(4-methyl-5-(1H-tetrazol-1-yl)pyridin-2-yl)acetic acid

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Reaction Steps

Lithium hydroxide monohydrate (19.2 mg, 0.458 mmol) was dissolved in 5 mL water then added to a methyl 2-(4-methyl-5-(1H-tetrazol-1-yl)pyridin-2-yl)acetate in tetrahydrofuran (15 mL). The reaction was stirred for 1 h then acidified with 1 N HCl to pH ˜3. The mixture was extracted with a mixture of THF/ethyl acetate (4×.). Dried over Na2SO4, filtered and evaporated concentrated to yield 2-(4-methyl-5-(1H-tetrazol-1-yl)pyridin-2-yl)acetic acid.

Provenance & Evidence