Trifluoromethanesulfonic acid → HCID 77230638, compound

Participants

Reaction Steps

tert-Butyl ethyl (6-nitro-4-methylpyridin-3-yl)propanedioate (7.4 g, 22.8 mmol) was dissolved in DCM (100 mL) and treated with trifluoromethanesulfonic acid (25 mL). The reaction mixture stirred 12 h, then was concentrated in vacuo and dried under high vacuum. The resulting residue purified by flash chromatography (eluted with 2−>10% hexanes/ethyl acetate) to provide title compound.

Provenance & Evidence