HCID 67515742, compound → HCID 77230645, compound

HRID 1502136Notes

Reaction equation

HRID 1502136 reaction equation
[CH3:1][C:2]([C:15]1[C:16]([CH3:24])=[N:17][C:18]([N+:21]([O-:23])=[O:22])=[CH:19][CH:20]=1)(C(OCC)=O)[C:3]([O:5][C:6](C)(C)[CH3:7])=[O:4]>C(O)(C(F)(F)F)=O.C(Cl)Cl>[CH3:24][C:16]1[C:15]([CH:2]([CH3:1])[C:3]([O:5][CH2:6][CH3:7])=[O:4])=[CH:20][CH:19]=[C:18]([N+:21]([O-:23])=[O:22])[N:17]=1

Participants

3

Reactant 1

HCID 67515742HCID 67515742, compound

Product 1

HCID 77230645HCID 77230645, compound

Reagents, catalysts & solvents 1

HCID 21863450Trifluoroacetic acid methylene chlorideSolvent

Procedure

A mixture of tert-butyl ethyl methyl(2-methyl-6-nitropyridin-3-yl)propanedioate (2.8 g, 8 mmol) in a mixed solution of TFA/DCM (30 mL/30 mL) was stirred over night at room temperature. The mixture was concentrated under reduce pressure to give ethyl 2-(2-methyl-6-nitropyridin-3-yl)propanoate.

Workup

  1. concentrationThe mixture was concentrated

Sources & evidence

ORD record
ord-0fca5c76d8d1426b819598fc55d4a95f
Source dataset
uspto-grants-2015_12
Patent number
US09206199B2

Reaction notes

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