Benzophenone imine → HCID 131734295, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of Pd2(dba)3 (1.9 mg, 0.0001 mmol), BINAP (5 mg, 0.008 mmol), and potassium tert-butoxide (62 mg, 0.55 mmol) in toluene (3 mL) was added tert-butyl (2-bromopyridin-4-yl)acetate (150 mg, 0.55 mmol) and benzophenone imine (140 μL, 0.83 mmol). The reaction was degassed for 15 minutes and then heated at 100° C. for 15 hours in a sealed tube. The reaction was then cooled to ambient temperature and concentrated in vacuo. The crude residue was dissolved ethyl acetate (200 mL), filtered over celite, and washed with water. The organic layers were dried over sodium sulfate, filtered and concentrated in vacuo. The crude material was purified via MPLC (0-100% EtOAc/Hex gradient) to afford title compound. LC-MS: (M+H)+373.

Provenance & Evidence