Methyl 2-(5-bromopyridin-3-yl)acetate → HCID 89619058, compound

HRID 1502146Notes

Reaction equation

HRID 1502146 reaction equation
Br[C:2]1[CH:3]=[C:4]([CH2:8][C:9]([O:11]C)=[O:10])[CH:5]=[N:6][CH:7]=1.[N:13]1(C2C=C(CC(O)=O)C=CN=2)[CH:17]=[N:16][N:15]=[N:14]1>>[N:13]1([C:2]2[CH:3]=[C:4]([CH2:8][C:9]([OH:11])=[O:10])[CH:5]=[N:6][CH:7]=2)[CH:17]=[N:16][N:15]=[N:14]1

Participants

3

Reactant 2

HCID 23398394Methyl 2-(5-bromopyridin-3-yl)acetateHCID 89619068HCID 89619068, compound

Product 1

HCID 89619058HCID 89619058, compound

Procedure

[5-(1H-Tetrazol-1-yl)pyridin-3-yl]acetic acid was prepared from methyl (5-bromopyridin-3-yl)acetate according to the procedure outlined for the preparation of intermediate [2-(1H-tetrazol-1-yl)pyridin-4-yl]acetic acid, except that in the final step the ester was hydrolyzed under basic conditions rather than acid.

Sources & evidence

ORD record
ord-687488908b1f4464a65e1cf7513e8e3e
Source dataset
uspto-grants-2015_12
Patent number
US09206199B2

Reaction notes

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