反应详情

To a solution of 2-(2-(1H-tetrazol-1-yl)pyrimidin-5-yl)acetic acid (100 mg, 0.485 mmol) in methanol (30 mL) was added sulfuric acid (1 mL, 18.8 mmol). Stirred at room temperature and sonicated to dissolve all acid starting material. Reaction was complete within about 2-3 min. The reaction was concentrated under reduced pressure, neutralized with saturated aqueous sodium bicarbonate, extracted with DCM (2 times), washed organics with brine, dried over magnesium sulfate. Solvent was removed under reduced pressure and residue dried on high vacuum overnight. LC/MS: [(M+1)]+=221.0;

1. customsonicated
2. dissolutionto dissolve all acid
3. customReaction
4. concentrationThe reaction was concentrated under reduced pressure
5. extractionextracted with DCM (2 times)
6. washwashed organics with brine
7. dry with materialdried over magnesium sulfate
8. customSolvent was removed under reduced pressure and residue
9. customdried on high vacuum overnight