Trifluoroacetic acid → 2-(5-fluoro-6-(1H-tetrazol-1-yl)pyridin-3-yl)acetic acid

Participants

Reaction Steps

To tert-butyl 2-(5-fluoro-6-(1H-tetrazol-1-yl)pyridin-3-yl)acetate (70 mg, 0.25 mmol) in DCM (0.50 mL) was added thioanisole (163 μl, 1.38 mmol) and TFA (241 μl, 3.13 mmol) at 0° C. The reaction mixture was stirred at rt for 5 h. The reaction mixture was concentrated to give the crude product, which was used in the next step without further purification: LC/MS: [(M+1-28)]+=196.5.

Provenance & Evidence