HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sulfuric Acid → Caproyl proline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sulfuric Acid | HCID 1118 | — |
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Decanoyl chloride | HCID 66982 | — |
| Reactant | L-Proline | HCID 145742 | — |
| Solvent | Water | HCID 962 | — |
| Product | Caproyl proline | HCID 18632633 | 92.7% |
Reaction Steps
Proline (manufactured by Ajinomoto Co., Inc., 34.54 g) was dissolved in water (100 g), and decanoyl chloride (manufactured by Tokyo Chemical Industry Co., Ltd., 52.01 g) and 25% aqueous sodium hydroxide solution were added while adjusting to pH 12. The mixture was neutralized with 75% sulfuric acid, and the aqueous layer was removed. Water and ethyl acetate were further added, and the aqueous layer was removed. Ethyl acetate was evaporated under reduced pressure to give decanoyl proline (68.12 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09211245B2 |
| Source dataset | uspto-grants-2015_12 |
| ORD ID | ord-c675f5da2bb54573ab36f57188f775b5 |
| Source note | uspto-grants-2015_12 |