Hydrochloric Acid → Sodium hydroxide rebamipide

Participants

Reaction Steps

12 ML of 10 N hydrochloric acid (14.2 g, 0.12 mol), 68 mL of purified water, and 200 mL of an aqueous solution containing some of the additives listed in Table 1 (the concentration of the additives is 5 fold of that in the desired suspension product that will be prepared) were mixed to prepare a hydrochloric acid-additives solution. To 700 mL of an aqueous solution of sodium hydroxide which was prepared by adding purified water to 4.4 g of sodium hydroxide (0.11 mol), 20 g of rebamipide (0.054 mol) was added and dissolved with heating to give a sodium hydroxide-rebamipide solution.

Provenance & Evidence