Acetic Acid → HCID 178427610, compound

Participants

Reaction Steps

83.8 mg (0.24 mmol) of N—(N-(2-(benzyloxy)ethyl)carbamimidoyl)-4-methylbenzenesulfonamide were dissolved under nitrogen in MeOH. A few mg of 10% Palladium over activated charcoal were added. 3 vacuo hydrogen flush were done before stirring vigorously the reaction under a H2 atmosphere. After 2 hours, no conversion was found by TLC (eluant AcOEt:pentane 9:1) and approximatively 5 times the amount of starting Palladium over activated charcoal was added. The rection was stirred overnight. The TLC showed the formation of a more polar product unless the reaction was far from being complete. 1 mL of acetic acid was added. One hour after the reaction was complete. The reaction was filtered over celite and the solvent evaporated to afford 62.8 mg (0.24 mmol) of N—(N-(2-hydroxyethyl)carbamimidoyl)-4-methylbenzenesulfonamide as a white solid (yield=100%).

Provenance & Evidence