2-Pyridinamine, 5-iodo- → HCID 77985002, compound

HRID 1502638Notes

Reaction equation

HRID 1502638 reaction equation
Br[CH2:2][C:3]([C:5]1[CH:6]=[CH:7][C:8]([N:11]2[CH:15]=[CH:14][N:13]=[N:12]2)=[N:9][CH:10]=1)=O.[NH2:16][C:17]1[CH:22]=[CH:21][C:20]([I:23])=[CH:19][N:18]=1>>[I:23][C:20]1[CH:21]=[CH:22][C:17]2[N:18]([CH:2]=[C:3]([C:5]3[CH:6]=[CH:7][C:8]([N:11]4[CH:15]=[CH:14][N:13]=[N:12]4)=[N:9][CH:10]=3)[N:16]=2)[CH:19]=1

Participants

3

Reactant 2

HCID 885792-Pyridinamine, 5-iodo-HCID 86717665HCID 86717665, compound

Product 1

HCID 77985002HCID 77985002, compound

Procedure

The obtained 5-(2-bromoacetyl)-2-(1H-1,2,3-triazole-1-yl)pyridine is allowed to react with 2-amino-5-iodopyridine in accordance with known methods (for example, the method described in a literature, Zhi-Ping Zhuang et al., J. Med. Chem., 2003, 46, p. 237-243), to obtain 6-iodo-2-[2-(1H-1,2,3-triazole-1-yl)pyridine-5-yl]imidazo[1,2-a]pyridine (FIG. 1, step 3).

Sources & evidence

ORD record
ord-b9cd7de648824044a97116c444433a0f
Source dataset
uspto-grants-2015_12
Patent number
US09211350B2

Reaction notes

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