Water → HCID 86717667, compound

Participants

Reaction Steps

31.9 mg (corresponding to 0.170 mmol) of 5-acetyl-2-(2H-1,2,3-triazole-2-yl)pyridine was dissolved in 1.0 mL of dichloromethane and 71 μL of triethylamine, and then 44.1 μL (corresponding to 0.51 mmol) of bromotrimethylsilane was dropped under ice cooling. The resulting solution was stirred over night at room temperature under argon gas atmosphere, and then, the reaction solution was supplemented with water and extracted 3 times with dichloromethane. The combined dichloromethane layer was washed with water and a saturated saline solution, and dried over anhydrous magnesium sulfate. The solvent was distilled off, the resulting residue was dissolved in 1.0 mL of tetrahydrofuran, and 33.3 mg (corresponding to 0.17 mmol) of N-bromosuccinimide was added thereto under ice cooling. The resulting solution was stirred at room temperature for 30 minutes. After the completion of the reaction, the solvent was distilled off under reduced pressure, and the residue was purified by flash silica gel column chromatography (elution solvent: dichloromethane/ethyl acetate=2/1), to obtain 20.2 mg (corresponding to 0.076 mmol) of 5-(2-bromoacetyl)-2-(2H-1,2,3-triazole-2-yl)pyridine (FIG. 2, step 2).

Provenance & Evidence