HCID 86675138, compound → HCID 86675137, compound

HRID 1502675Notes

Reaction equation

HRID 1502675 reaction equation
[Br:1][C:2]1[CH:23]=[C:22](/[CH:24]=[CH:25]/[CH:26]([C:31]2[CH:36]=[C:35]([Cl:37])[C:34]([Cl:38])=[C:33]([Cl:39])[CH:32]=2)[C:27]([F:30])([F:29])[F:28])[CH:21]=[CH:20][C:3]=1[C:4]([NH:6][CH:7]1[CH2:12][CH2:11][N:10](C(OC(C)(C)C)=O)[CH2:9][CH2:8]1)=[O:5]>Cl.O1CCOCC1>[Br:1][C:2]1[CH:23]=[C:22](/[CH:24]=[CH:25]/[CH:26]([C:31]2[CH:32]=[C:33]([Cl:39])[C:34]([Cl:38])=[C:35]([Cl:37])[CH:36]=2)[C:27]([F:30])([F:28])[F:29])[CH:21]=[CH:20][C:3]=1[C:4]([NH:6][CH:7]1[CH2:12][CH2:11][NH:10][CH2:9][CH2:8]1)=[O:5]

Participants

3

Reactant 1

HCID 86675138HCID 86675138, compound

Product 1

HCID 86675137HCID 86675137, compoundYield 94.7%

Reagents, catalysts & solvents 1

HCID 204431481,4-Dioxane hydrochlorideSolvent

Procedure

(E)-tert-Butyl 4-(2-bromo-4-(4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)but-1-enyl)benzamido)piperidine-1-carboxylate (0.75 g, 1.11 mmol) was added to dioxane HCl (10 mL) at 0° C. and was stirred for 18 h. The reaction mixture was concentrated under reduced pressure and triturated with diethylether to afford the compound as a light brown solid (0.6 g, 88%).

Workup

  1. concentrationThe reaction mixture was concentrated under reduced pressure
  2. customtriturated with diethylether

Sources & evidence

ORD record
ord-cfd8956a3b0343db960d2c24a8f4d8ba
Source dataset
uspto-grants-2015_12
Patent number
US09210927B2

Reaction notes

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