Trifluoroacetic acid → HCID 86722597, compound

Participants

Reaction Steps

To a solution of (E)-N-(2-amino-2-methylpropyl)-4-(4,4,4-trifluoro-3-(3,4,5-trichlorophenyl)but-1-en-1-yl)-2-(trifluoromethyl)benzamide (155 mg, 0.283 mmol), 1-[bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium 3-oxid hexafluorophosphate (HATU) (118 mg, 0.311 mmol), and 2,2,2-trifluoroacetic acid (0.026 mL, 0.340 mmol) in DMF (1 mL) was—added N-methylmorpholine (0.062 mL, 0.566 mmol). The mixture was stirred at ambient temperature for 18 h, —then partitioned between water and EtOAc. The organic phase was washed with water and—brine, —dried (sodium sulfate) and concentrated—under reduced pressure. Purification by column chromatography eluting with EtOAc in hexanes (10%-100%)—afforded the title compound as a yellow oil (26 mg, 13%).

Provenance & Evidence